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Submitted: 07 September 2010 Modified: 09 March 2018
HERDIN Record #: PCHRD09071012092968

A case series using methylene blue for sentinel lymph node biopsy in breast cancer at St. Luke's Medical Center.

Jonathan C. Nolasco,
Ma. Cecilia  Pagdanganan

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Sentinel lymph node biopsy has not gained popularity in the Philippines, perhaps the reason being the unavailability of resources. The use of methylene blue may change this situation.
OBJECTIVE: The authors intend to demonstrate that methylene blue may be used as an alternative dye in sentinel lymph node biopsy for breast cancer with satisfactory results.
METHODS: Twenty patients diagnosed with breast cancer underwent sentinel lymph node biopsy after injection with methylene blue dye, followed by complete axillary dissection. Histologic evaluation of the nodes was done using H&E stain.
RESULTS: The identification rate was 95%, with no false negatives.
CONCLUSION: Sentinel lymph node biopsy using methylene blue can be done with satisfactory results.

Publication Type
Journal
Publication Sub Type
Case Series
Title
Philippine Journal of Surgical Specialties
Frequency
Quarterly
Publication Date
April-June 2010
Volume
65
Issue
2
Page(s)
67-69
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext pdf (Request Document)
1. Giuliano, AE , Korgan, DM , Guenther, JM , Morton, DL . "Lymphatic mapping and sentinel lymphadenoectomy for breast cancer" Ann Surg 220, 391-398, 1994. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234400/
2. Nolasco, JC , Pagdanganan, MC , Dizon, AC , Galang, CJ , Gonzales, FC , Ramos, NL . "Sentinel lymph node biopsy in breast cancer using methylene blue: a preliminary report" St. Luke 2(2): 15-18, 2003
3. Cruz, MD , Qua, JC , Lao, LL . "Accuracy of isosulfan blue dye in sentinel node biopsy for breast cancer" Phillip J Surg Spec 63(2): 66-71, 2008
4. Nos, C , Freneaux, , Guilber, S , Falcon, MC , Salmon, RJ , Clough, KB . "Sentinel lymph node detection for breast cancer: which patients are best suited for the patent blue dye only method of identification" Ann Surg Oncol 8(5): 438-443, 2001
5. Thevarajah, S , Huston, TL , Simmons, RM . "A comparison of the adverse reactions associated with isosulfan blue vs methylene blue dye in sentinel lymphadenectomy for breast cancer" Am J Surg 189, 236-239, 2005
6. Stefanutto, TB , Shapiro, WA , Wright, PM . "Anaphylactic reaction to isosulfan blue" Br J Anesth 89(3): 527-528, 2002
7. Blessing, WD , Stolier, AJ , Teng, SC , Bolton, JS , Fuhrman, GM . "A comparison of methylene blue and lymphazurin in breast sentinel node mapping" Am J Surg 184, 341-345, 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/12383897
8. Borgstein, PJ . "Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probc detection" J Am Coll Surg 186, 275-283, 1998
9. Nour, A . "Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients" Breast J 10(5): 388-391, 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15327490