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Submitted: 03 August 2018 Modified: 12 December 2018
HERDIN Record #: R07-USC-18080309471771

The effect of the seed extract of Cobra vine Ipomoea nil Linn. 1957 on fatigue using forced-swimming test (FST) on male sprague dawley rats.

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Ipomoea nil commonly called Cobra vine is known for its folkloric use to treat fatigue. The overall purpose of this study was to evaluate the effects of the plant extract on fatigue. The Ipomoea nil seeds underwent decoction. There were five groups: Groups A, B and C were the treated groups, Group D was untreated group and Group E was the normal control group. Groups A, B, C and D were subjected to Forced Swimming Test (FST) before the start of the 6-day treatment to get fatigue  induced values then after 6-day treatment and after another 6 days treatment. Arbitrary doses of 100mg/200g BW, 250mg/200g BW and 450mg/200g BW for groups A, B and C respectively, was administered to the rats once a day. Blood biochemical parameters namely glucose and hemoglobin were evaluated as biomarkers of physical fatigue. The treatments were found to increase the glucose and haemoglobin levels compared to the control group. Statistical analysis for all groups in 6 days treatment and 12 days treatment showed significant difference among groups and between treatment  days in glucose and hemoglobin. Twelve days treatment was more effective than 6 days treatment and the higher the dose the more effective it was in treating fatigue. The three doses, showed increase in glucose and hemoglobin levels and increase swimming time, indicating that Ipomoea nil has antifatigue activity and could elevate exercise performance.

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Pharmacy
Publication Date
March 2014
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / An224sa Fulltext Print Format (Ask the Information Officer)
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