Report an error   

HERDIN Record #: R07-USC-18080309471771 Submitted: 03 August 2018 Modified: 12 December 2018

The effect of the seed extract of Cobra vine Ipomoea nil Linn. 1957 on fatigue using forced-swimming test (FST) on male sprague dawley rats.

See More

Ipomoea nil commonly called Cobra vine is known for its folkloric use to treat fatigue. The overall purpose of this study was to evaluate the effects of the plant extract on fatigue. The Ipomoea nil seeds underwent decoction. There were five groups: Groups A, B and C were the treated groups, Group D was untreated group and Group E was the normal control group. Groups A, B, C and D were subjected to Forced Swimming Test (FST) before the start of the 6-day treatment to get fatigue  induced values then after 6-day treatment and after another 6 days treatment. Arbitrary doses of 100mg/200g BW, 250mg/200g BW and 450mg/200g BW for groups A, B and C respectively, was administered to the rats once a day. Blood biochemical parameters namely glucose and hemoglobin were evaluated as biomarkers of physical fatigue. The treatments were found to increase the glucose and haemoglobin levels compared to the control group. Statistical analysis for all groups in 6 days treatment and 12 days treatment showed significant difference among groups and between treatment  days in glucose and hemoglobin. Twelve days treatment was more effective than 6 days treatment and the higher the dose the more effective it was in treating fatigue. The three doses, showed increase in glucose and hemoglobin levels and increase swimming time, indicating that Ipomoea nil has antifatigue activity and could elevate exercise performance.

Publication Type
Thesis Degree
Publication Date
March 2014
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / An224sa Fulltext Print Format
1. Cao, S , Shang , H , Wu, W , Du, J , Putheti, R . "Evaluation of Anti-athletic Fatigue Activity of Schizandra chinensis Aqueous Extracts in Mice" African Journal of Pharmacy and Pharmacology 3(11): 593-597, 2009
2. Coombes, J S, McNaughton, L R. "Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise" J. Sports Med. Phys. Fitness 40, 240-246, 2000
3. Ding, X , Tang, K , Lu, P , Putheti, R . "Antifatigue Effects of Polydatin from Chinese Herb Polygonum Cuspidatum in Swimming Mice" African Journal of Microbiology 3(7): 358-361, 2009
4. Jin, H , Wei, P . "Anti-Fatigue Properties of Tartary Buckwheat Extracts in Mice" International Journal of Molecular Sciences 12, 4770-4780, 2011
5. JiPing, S . "Antifatigue Effect of Aqueous Extract of Salvia in Endurance Training Rats" International Journal of the Physical Sciences 6(11): 2697-2700, 2011
6. Jones, K . "Blood Collection from the Lateral Saphenous Vein in Mice and Rats SOP" UBC Animal Care Guidelines 2, 1-5, 2012
7. Li, T , Li, W . "Impact of polysaccharides from Cordyceps on antifatigue in mice" Scientific Research and Essay 4(7): 705-709, 2009
8. Meira, M , Silva, E , David, J M, David, J P. "Review of the Genus Ipomoea: traditional uses, chemistry and biological activities" Brazilian Journal of Pharmacognosy 22(3): 627-713, 2011
9. Prasad, M P, Khanum, F . "Antifatigue Activity of Ethanolic Extract of Ocimum sanctum in Rats" Research Journal of Medicinal Plant 6(1): 37-46, 2012
10. Seo, S W, Koo, H N, An, H J, Kwon, K B, Lim, B C, Seo, E A, Ryu, D G, Moon, G , Kim, H Y, Kim, H M, et. al., . "Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rats." World J. Gastroentero 11, 597-599, 2005
11. Tang, K , Nie, R , Jing, L , Chen, Q . "Anti-athletic fatigue activity of saponins (Ginsenosides) from American ginseng (Panax quinquefolium L.)" African Journal of Pharmacy and Pharmacology 3(6): 301-306, 2009
12. Wu, J L, Wu, Q P, Huang, J M, Chen, R , Cai, M , Tan, J B. "Effects of L-malate on physical stamina and activities of enzymes related to the malate-aspartate shuttle in liver of mice" Physiol. Res. 56, 213-220, 2007
13. Xiang, C , Xiaowei, Z , Xiaojuan, L , Yong, H , Guohai, Z , Xueqi, G , Jin, Q , Yuexian, P , Yongping, Y . "Effects of crude polysaccharides from Purselane on fatigue induced by forced swimming" African Journal of Biotechnology 11(4): 923-929, 2012
14. Xu , Z , Wang, C . "Effects of Radix puerariae (Ge Gen) Water Extract on Exercise-Induced Fatigue Mice" Journal of Animal and Veterinary Advances 11(10): 1722-1726, 2011
15. Zhang, H J, Wu, Y J, Cheng, Y Y. "Analysis of " J. Pharm. Biomed. Analysis 31, 175-183, 2003
16. Zhang, X , Ren, F , Huang, W , Ding, R , Zhou, Q , Liu, X . "Anti-Fatigue Activity of Extracts of Stem Bark from Acanthopanax senticosus" International Journals of Molecular Sciences 16, 28-37, 2010
17. Zhang, Y N, Li, H P, Zhang, J , Han, L K. "Effect of Saponins of Panax quinquefolium on Inhibiting High-Fat Diet Induced Obesity and Lipase Activity of Mice" J. Jilin. Agric. Univ. 27, 519-523, 2005
18. Brown, B . Biological Membranes 2010. 1-34. (Volume 8)
19. Shinners, L . Untypification for Ipomoea nil (L.) Roth 231-234. (Volume 14,)