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Submitted: 20 July 2013 Modified: 19 September 2013
HERDIN Record #: R07-USC-13072010170598

Anti-ulcer effect of noni (morinda citrifolia linn) leaf extract on the damaged gastric mucosa of sprague dawley rats


The study was designed to investigate the anti-ulcer activity of Noni (Morinda citrifolia) using the Aspirin-induced gastric mucosal damage and pyloric ligation method. Gastric ulcers were induced to the rats by oral administration of Aspirin at 200mg per kilogram body weight dose for two days preceding the treatment administration. The plant extract was administered at a dose of 100, 500 and 1000mg/kg dose everyday for eight days. Ranitidine (20mg/kg) was used as the positive control. The antiulcer activity was accessed by determining and comparing the in the test group with that of the positive group. The sizes of gastric mucosal lesions were based for the computation of the ulcer index and percent protection. The gastric juice was diluted and measure in a pH meter. M. citrifolia 100mg/kg showed maximum inhibition of gastric acid, having the diluted solution a pH of 6.33. Maximum percent protection from the ulceration also showed highest at 100mg/kg followed by the 500 and 1000 mg/kg with the percent protection of 69.79%, 34.20% and 11.48% respectively. The antiulcer activity of the M. citrifolia extract, however, less than that of the ranitidine but results suggests that M. citrifolia possess an antiulcer property. The anti-ulcer could be due to presence of flavonoids, which is gastroprotective, anti-secretory and cytoprotective. Decrease in anti-ulcer activity as the dose increase may be due to the presence of carboxylic acids. Carboxylic acids were proven to be present in the ethanolic leaf extract of M. citrifolia.

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Pharmacy
Publication Date
October 2011

Objectives

The purpose of the study was to determine the anti-ulcer effects of Morinda Citrifolia on Gastric mucosal damage of the albino rat. Specifically, the study sought to determine:
1. the pH of gastric juice secretion of the albino rat
2. the size of lesions of the stomach after treatment of three different doses of test solution and positive control
3. the percent protection of the Morinda citrifoliaextract compared to the positive and untreated controls based on the ulcer index

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