Case Report: A 16-year-old male was a newly diagnosed case of Nephrotic syndrome, he was on his 4th day of full dose prednisone therapy when he was noted to have swelling of the face, abdominal enlargement, occasional cough with associated hemoptysis. There was gradually enlarging right lower extremity, his toes developed cyanosis and necrosis with associated intolerable pain, which eventually revealed deep venous thrombosis.
Discussion: Thromboembolic disease specifically involving the venous circulation may include Deep Venous Thrombosis (DVT) of the deep veins of the leg or arm, often resulting in potentially life-threatening emboli to the lungs or debilitating venous alveolar dysfunction and chronic leg swelling. The risk of developing renal vein thrombosis in nephritic patients is increased due to their hypercoagulable state.
Conclusion: Although DVT is rare in children, early detection is important, requiring a detailed case history in the presence of an edematous, painful, and hot limb that are keys to the diagnostic suspicion. The imaging test and the laboratory tests will confirm the diagnosis, and anticoagulate treatment will prevent complications.
General Objective: to present a case of Deep Venous Thrombosis, Renal Vein thrombosis and Pulmonary embolism in a Nephrotic patient.
Specific Objectives: To describe the development of thromboembolic disease in Nephrotic Syndrome and to discuss its pathophysiology and management.
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