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HERDIN Record #: CAR-BGHMC-12101115042656 Submitted: 11 October 2012 Modified: 26 November 2012

Comparison of Nifedipine vs Isoxuprine in arresting preterm labor: a case report .

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Spontaneous preterm labor and delivery account for approximately one-third of preterm births, which is the major contributing factor to perinatal mortality and morbidity in obstetric practice in the developed world. In order to address this problem the aim is to both prevent the onset of preterm labor and to treat the acute condition. While controversial, tocolytic drugs are widely used and seen by many to improve neonatal outcome; however, the choice of first-line tocolytic therapy to achieve this aim is currently actively debated. This is a randomized study to be conducted to determine the efficacy of oral Nifedipine versus Isoxuprine drip in arresting preterm labor among pregnant women admitted at Baguio General Hospital and Medical Center during March 2010 - October 2011.


Nifedipine group has a 95% successful pregnancy outcome while Isoxuprine group has 72.5% successful pregnancy outcome . Pregnancy was prolonged to more that 7 days in 72.5% cases in the Nifedipine as compared to 42.5% cases in the Isoxuprine group. Nifedipine has less maternal side effects compared to isoxuprine. Nifedipine is cheaper than isoxuprine.


Nifedipine is more effective in having a successful pregnancy outcome and is more efficient in delaying delivery up to 7 days than Isoxuprine. It is also cheaper than Isoxuprine thus, more cost- effective. However, there is no statistically significant difference between the two tocolytics agents in terms of maternal morbidities.

Publication Type
Research Report


It is the purpose of the study to determine the efficacy and safety of oral Nifedipine vs Isoxuprine drip in arresting preterm labor among pregnant women who were admitted at a tertiary hospital in Baguio City. To assess the effectiveness of Nifedipine on pregnancy outcome as compared to Isoxuprine, evaluate the extent to which delivery was delayed with Nifedipine as compared to Isoxuprine, and evaluate the effect of Nifedipine on maternal morbidity in comparison to Isoxuprine and sudy the frequency oc common side effects of Nifedipine and Isoxuprine and compare them in this aspect. Lastly, to copare the cost-effectiveness between Nifedipine and Isoxuprine.

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Baguio General Hospital and Medical Center Fulltext Print Format
1. Williams obstetrics McGraw Hill, 2001.
2. "Preterm labor and birth" Creasy & Resnik’s Maternal-Fetal Medicine, 2009. , 2009
3. Moynihan, A. T., Smith, T. J.. "Relaxant effect of Nifedipine in uterine smooth muscle and the BKca channel. " Am J Obstet Gynecol, 2008. 198:237e1-237e8 198, 237, 2008
4. "Nifedipine pharmacokinetics and plasma levels in the management of preterm labor " Am J Ther 14(4): 346-350, 2007
5. "A comparative study between Nifedipine and Isoxuprine in the suppression of preterm labor" Kathmandu University Medical journal 1(2): 85-90, 2003
6. "Tocolysis with Ritodrine: a comparative study in preterm labor. " Pak J Med 22(1): 64-66, 2008
7. "Tocolytic treatment for the management of preterm labor: a systematic review" . Singapore Med J 47(5): 361, 2006
8. (). Genetic variation associated with preterm birth. . .
9. Ingemarsson , I. . (). An update on the controversies of tocolytic therapy for the prevention of preterm birth. . t .
10. ().