Report an error   


Submitted: 07 February 2012 Modified: 11 November 2016
HERDIN Record #: PCHRD12020711103129

Treatment of juxtapapillary toxoplasmic retinochoroiditis with intravitreal clindamycin and dexamethasone injection.


OBJECTIVE: To report the use of intravitreal clindamycin and dexamethasone in the treatment of juxtapapillary toxoplasmic retinochoroiditis.


METHODS: This is a case report.


RESULTS: A 34-year-old female was diagnosed serologically and clinically with juxtapapillary toxoplasmic retinochoroiditis in the left eye and treated with intravitreal injection of clindamycin 1.0 mg in 0.1 mL and 4.0 mg of dexamethasone in 0.1 mL. Treatment with oral trimethoprim/ sulfamethoxazole 160/800 mg was continued for 6 weeks. The primary outcome measures were change in Snellen visual acuity, resolution of inflammation, pre- and posttreatment fluorescein angiograms, and adverse events.


CONCLUSION: Intravitreal injection of clindamycin and dexamethasone was well tolerated and associated with resolution of vitreous and optic-nerve inflammation, offering an additional option in the treatment of juxtapapillary toxoplasmic retinochoroiditis.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Ophthalmology
Frequency
Semi-Annual
Publication Date
July-December 2008
Volume
33
Issue
2
Page(s)
63-65
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 62 Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Library Fulltext External Link (View)
1. Holland, G N, Lewis, K G, O, G R. "Ocular toxoplasmosis: A 50th anniversary tribute to the contributions of Helenor Campbell Wilder Foerster" Arch Ophthalmol 120(8): 1081-1084, August 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/12149063
2. Nussenblatt, R B. Ocular toxoplasmosis. Uveitis: Fundamentals and Clinical Practice, 3rd ed New York: Elsevier, 2004. 214-234.
3. Holland, G N. "Ocular toxoplasmosis: A Global reassessment. Part II: Disease manifestations and management" Am J Ophthalmol 137(1): 1-17, January 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/14700638
4. Soheilan, M , Sadoughi, M , Ghajarnia, M , Dehghan, M H, Yazdani, S , Behboudi, H , Anisian, A , Peyman, G A. "Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis" Ophthalmology 112(11): 1876-1882, November 2005. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/16171866
5. Kishore, K , Conway, M D, Peyman, G A. "Intravitreal clindamycin and dexamethasone for toxoplasmic retinochoroiditis" Ophthalmic Surg Lasers 32(3): 183-192, May 2001-June 2001. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11371084